XClose

Euro Ewing Consortium

International Clinical Trials to Improve Survival from Ewing Sarcoma
Menu

Translational ResearchWP3

Biobanking, reference pathology and molecular characterisation

Objectives

  1. Harmonization of biospecimen collection, storage, distribution, and virtual tumour bank
  2. Reference pathology
  3. Provision of high quality biomaterial
  4. Expression of putative biomarkers in Tissue Microarray (TMA)
  5. Molecular characterization of tumour samples

WP4

Biomarkers of response, toxicity and outcome

Objectives

  1. Examine the miRNA profile in bone marrow aspirates, whole blood and plasma taken at diagnosis to identify the most informative compartment and minimal predictive miRNA signature (in that compartment) of toxicity, response and outcome.
  2. Quantify the level of EWS-ETS circulating tumour DNA (ctDNA) in plasma at diagnosis, during treatment and on follow up.
  3. Quantify the level of EWS-ETS mRNA in blood to detect circulating tumour cells (CTCs) at diagnosis, and during treatment.